Reduction of emergence reactions like cough, hypertension after general anaesthesia with intratracheal lignocaine as compared to intratracheal normal saline in endoscopic transsphenoidal pituitary surgery patients

Evaluation of intratracheal lignocaine as compared to normal saline to reduce emergence reactions in the patients undergoing endoscopic transphenoidal pituitary surgery : a double blind randomized controlled trial

Status

Recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/04/013011

Enrollment

Registered

2018-04-04

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients undergoing endoscopic trans sphenoidal pituitary surgery

Interventions

Intervention1: Lignocaine: Lignocaine is commonly used local anaesthetic drug . In this study we will be using 1 mg/kg of body weight (or 0.05ml/kg of body weight) of 2% lignocaine intratracheally du

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients between 18 â?? 65 years of age. 2. ASA grade I & II patients. 3. Patients of Pituitary tumor posted for elective endoscopic transphenoidal surgery for tumor excision

Exclusion criteria

Exclusion criteria: 1. Refusal of consent 2. Patients with history of smoking or chronic cough 3. Patients with history of upper respiratory tract infection (URI) in last 8 weeks 4. Patients with bleeding disorders 5. Previous laryngeal or tracheal surgery or pathology 6. Patients with history of gastric reflux 7. Patients with preoperative GCS 8. Patients with pulmonary disease, renal, cardiac or hepatic disorders, uncontrolled diabetes 9. Patients with clinical sign of hypothyroidism 10. Patients with BMI > 35kg/mt2 11. Patients with the history of hypertension (controlled or uncontrolled) 12. Patients with upper respiratory tract infection 13. Patients having history of allergic reactions to study drug Post inclusion exclusion : 1. Need of more than 2 attempts of tracheal intubation or need of bougie for tracheal intubation 2. Patients who can not be extubated and are planned for elective ventilation

Design outcomes

Primary

Measure	Time frame
To determine the effect of intratracheal lidocaine on suppressing the cough on emergence from general anesthesia in patients undergoing endoscopic transphenoidal pituitary surgery.Timepoint: During emergence from general anesthesia after the end of the surgery	—

Secondary

Measure	Time frame
To determine effect of intratracheal lignocaine on HR and BP changes To determine the effect of intratracheal lignocaine on the emergence time, extubation time and recovery time To determine effect of intratracheal lignocaine on the neurological recovery in the early postoperative period. To determine effect of intratracheal lignocaine on arterial blood gas (ABG) in the early postoperative period Timepoint: During the maintenance phase and emergence phase of general anesthesia	—

Measure

Time frame

To determine effect of intratracheal lignocaine on HR and BP changes To determine the effect of intratracheal lignocaine on the emergence time, extubation time and recovery time To determine effect of intratracheal lignocaine on the neurological recovery in the early postoperative period. To determine effect of intratracheal lignocaine on arterial blood gas (ABG) in the early postoperative period Timepoint: During the maintenance phase and emergence phase of general anesthesia

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Countries

India

Contacts

Public ContactRuhi Mamualiya

AIIMS New Delhi

pandiamihir@gmail.com98683978203

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026