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Assaying and understanding absorption of vitamin B12 and its deficiency by using safe and reliable methods.

Measurement of the absorption of vitamin B12, and the estimation of functional deficit in vitamin B12 deficiency, by stable isotope labeled methods

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/04/012957
Enrollment
80
Registered
2018-04-03
Start date
Unknown
Completion date
Unknown
Last updated
2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Stable isotopically labelled vitamin B12 and sodium propionate: Stable isotopically labelled 13C-vitamin B12 and 13C-sodium propionate Control Intervention1: Nil: Nil

Sponsors

Department of Biotechnology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Healthy adults male of BMI <25kg/m2 will be included in the study.

Exclusion criteria

Exclusion criteria: Individuals who are diagnosed; 1) Anemia 2) Use of drug that would interfere with B12 absorption 3) Unrecognized B12 malabsorption 4) Evidence of chronic infections such as HIV, VDRL, Hepatitis surface antigen (HBsAg).

Design outcomes

Primary

MeasureTime frame
To develop a state of art stable isotope labeled vitamin B12 absorption method that mimics the radioactive Schillings test to accurately estimate the absorption of vitamin B12. To define a method for measuring B12 flux through the propionate metabolism pathway that is regulated by vitamin B12, as an in vivo method to functionally measure vitamin B12 deficiency. Timepoint: One day measurement for each of the study outcome.—

Secondary

MeasureTime frame
Validation of vitamin B12 absorption measurements against active B12 (holo-transcobalamin).Timepoint: One day measurement.—

Countries

India

Contacts

Public ContactSarita

St. Johns Medical College

a.kurpad@sjri.res.in08049466321

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 25, 2026