Comparison of effect on muscle paralysis and recovery of rocuronium between anaesthesia with isoflurane or propofol in spine surgery.

Comparison of neuromuscular blocking effects and recovery characteristics of rocuronium between steady state isoflurane or propofol anaesthesia in spinal fixation surgery.

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/04/012919

Enrollment

Registered

2018-04-02

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Posted for spinal fixation surgery

Interventions

Intervention1: Isoflurane inhalation: Isoflurane inhalation gradually increasing from 0.4 to 5% for maintaining the BIS 60-- from just before induction to 5 min after intubation. Control Interventio

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with physical status ASA I or II. 2.Patients who have given written consent for taking part in the study. 3.Patients scheduled for spinal instrumentation surgery.

Exclusion criteria

Exclusion criteria: 1.ASA physical status III or IV with compromised renal or liver function or respiratory disease. 2.Patients with major comorbidities like diabetes or hypertension. 3.Patients whose body weight is 30% more or less their ideal body weight. 4.Patients with moderate to severe cardiovascular diseases. 5.Patients those receiving medication known to interact with neuromuscular blocking drugs. 6.Patients having coagulopathies.. 7.Patients with allergic diasthesis. 8.Patients with pregnancy or breast feeding.

Design outcomes

Primary

Measure	Time frame
recovery time indexTimepoint: The time interval between the recovery of TI from 25%-75%	—

Secondary

Measure	Time frame
a.changes in pulse rate and blood pressure. b.Continuous monitoring of heart rate, noninvasive blood pressure (NIBP), capillary blood O2 saturation (SpO2),end tidal CO2(EtCo2), bispectral Index (BIS). c.By the use of TOF guard the following variables of neuromuscular block will be obtained for both groups . Timepoint: 1. Time taken after administration of rocuronium for intubation to reach TOF 0. 2. Time taken for appearance of T1 in TOF. 3. Clinical duration: Time after injection of last cumulative dose of muscle relaxant until 25%of recovery of TI. 4. Recovery index: Time interval during which TI recovered from 25%-75% of control.	—

Measure

Time frame

a.changes in pulse rate and blood pressure. b.Continuous monitoring of heart rate, noninvasive blood pressure (NIBP), capillary blood O2 saturation (SpO2),end tidal CO2(EtCo2), bispectral Index (BIS). c.By the use of TOF guard the following variables of neuromuscular block will be obtained for both groups . Timepoint: 1. Time taken after administration of rocuronium for intubation to reach TOF 0. 2. Time taken for appearance of T1 in TOF. 3. Clinical duration: Time after injection of last cumulative dose of muscle relaxant until 25%of recovery of TI. 4. Recovery index: Time interval during which TI recovered from 25%-75% of control.

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Countries

India

Contacts

Public ContactSaikat Niyogi

IPGMER

saikatneuro1972@gmail.com9831732443

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026