Health Condition 1: null- Adult patients (aged between 18 and 75y) of either sex undergoing emergency laparotomy under general anaesthesia will be recruited in this study.
Conditions
Interventions
Intervention1: Decremental PEEP titration: Recruitment maneuver followed by decremental PEEP titration targeting least driving pressure
Control Intervention1: Fixed PEEP: A PEEP of 5-6 cm H20 througho
Sponsors
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients (aged between 18 and 75y) of American Society of Anaesthesiologists physical status I or II, of either sex undergoing emergency laparotomy under general anaesthesia requiring arterial cannulation for intraoperative management will be recruited in this study.
Exclusion criteria
Exclusion criteria: 1. Patients or relativeâ??s refusal to participate in the study 2. Patients undergoing elective laparotomy 3. Known COPD or other chronic lung diseases 4. Known deformity of chest wall or thoracic spine 5. Pre-existing significant cardiac, renal and hepatic diseases 6. Intraoperative massive blood loss or massive transfusion 7. Patients who are on high dose of vasopressor (defined as noradrenalin > 10mcg/m)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PaO2/FiO2Timepoint: At the end of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Requirement of postoperative oxygen therapy 2. SaO2/FiO2 ratio after 30 minutes after extubation 3. Number of patients requiring supplemental oxygen to maintain SaO295% 4. Incidence of postoperative pulmonary complications (atelectasis, pneumonia, respiratory failure, pulmonary edema) within 7d of surgery 5. Incidence of barotrauma 6. Length of post-operative hospital stay 7. Length of ICU stay Timepoint: At the end of surgery | — |
Countries
India
Contacts
Public ContactDr Souvik Maitra
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed