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Effect of Various Drugs To Improve Pain Relief After Breast Cancer Surgery

A study to compare postoperative analgesia in patients undergoing modified radical mastectomy under epidural ropivacaine alone or using butorphanol versus fentanyl as adjuvant to ropivacaine

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/03/012876
Enrollment
90
Registered
2018-03-27
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- breast cancer

Interventions

Intervention1: epidural injection of ropivacaine alone versus butorphanol or fentanyl as adjuvant to ropivacaine: To compare postoperative pain relief using epidural ropivacaine, ropivacaine-butorphan
Group B will receive 6ml of 0.25% ropivacaine with butorphanol 1ml (1mg/ml) and 1 ml normal saline through epidural route.
Group C will receive 6ml of 0.25% ropivacaine with 2 ml fentanyl (100 micrograms) through epidural route. The post operative analgesia will be given as epidural top ups in the form of ropivacaine(0.12

Sponsors

Sri Guru Ram Das Institute Of Medical Sciences And Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade 1 & 2

Exclusion criteria

Exclusion criteria: 1. Patients having bleeding diathesis 2. Patients on any anticoagulant therapy 3. Patients with known hypersensitivity to local anaesthetics or study drugs. 4. Patients having history of drug abuse 5. Patients who are mentally retarded 6. Patient suffering from uncontrolled asthma, cardiac, respiratory, renal, thyroid, hepatic and CNS disorders. 7. Patients with local sepsis or spinal deformity.

Design outcomes

Primary

MeasureTime frame
Duration Of Postoperative AnalgesiaTimepoint: Duration Of Analgesia From Drug Administration To VAS Equals To Or More Than 4 in Postoperative Period In First 24 Hours

Secondary

MeasureTime frame
1.Intraoperative Haemodyanamic Stability 2.Total Dose Of Postoperative Analgesic RequirementTimepoint: 1. Intraoperative Haemodyanamical Stability Upto End of Surgery 2. In First 24 Hours

Countries

India

Contacts

Public ContactDr Ishpuneet singh

Sri Guru Ram Das Institute Of Medical Sciences And Research

chiteshwarwalia@gmail.com9878339933

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026