Health Condition 1: null- The trial studied incidence and severity of post spinal hypotension in elective LSCS in parturients who were receiving pharmacological prophylaxi to prevent said maternal hypotension.
Conditions
Interventions
Intervention1: EPHEDRINE: Ephedrine is a mixed action sympathomimetic drug which is commonly used to prevent or treat post spinal hypotension in caesarean sections.
Control Intervention1: GLYCOPYRROLA
Sponsors
Amit Vikram Das
Eligibility
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists Physical Status II (TWO) - Pregnancy with/without well controlled gestational diabetes/hypothyroidism/asthma 2. Body Mass Index range : 18 - 30 kg/m2 3. Nil Per Oral since 6 hours for solids and 3 hours for liquids.
Exclusion criteria
Exclusion criteria: 1. Baseline systolic blood pressure 2. Patients with anaemia (Hb 3. History of hypertension (gestational/chronic) 4. History of cardiovascular and cerebrovascular disease 5. Other contraindications to spinal anaesthesia 6. Subject refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EPHEDRINE WAS FOUND TO BE BETTER THAN GLYCOPYRROLATE IN PREVENTING POST SPINAL HYPOTENSION IN PARTURIENTS UNDERGOING ELECTIVE CAESAREAN DELIVERYTimepoint: -Baseline heart rate and blood pressure was the first recorded reading after shifting patient to OT table. -Intramuscular study drug given thereafter. -After IM injection, 3 successive readings of blood pressure and heart rate at 5 minute intervals taken. - Spinal anaesthetic given 15 minutes after IM injection. - After spinal, heart rate and blood pressure measured every minute for first 5 minutes and then every 5 minutes for 55 minutes or till the end of the surgery, whichever is sooner. | — |
Secondary
| Measure | Time frame |
|---|---|
| Parturients receiving intramuscular ephedrine prophylaxis required lesser rescue drug phenylephrine for correction of any consequent hypotension, as compared to the glycopyrrolate group.Timepoint: Phenylephrine was administered in boluses of 50 mcg if systolic blood pressure dropped less than 100 mmHg with in 2-3 mins after giving spinal anaesthesia | — |
Countries
India
Contacts
Public ContactAmit Vikram Das
Kasturba Medical College, Manipal
Outcome results
None listed