Comparison of the Effect of Zoledronic Acid versus a Structured Exercise Programme in Osteoporosis

A Randomized Controlled Trial to Compare the Effect of Zoledronic Acid versus a Structured Exercise Programme in Primary Osteoporosis

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/03/012837

Enrollment

200

Registered

2018-03-26

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Primary Osteoporosis

Interventions

Intervention1: Zoledronic Acid: 5mg/100ml single, intravenous infusion (once)immediately

Supplementation with Calcium and Vitamin D for 1 year Control Intervention1: Structured Exercise Programme: For the first three months, gradually increasing walking and running to 20 minutes. After t

Eligibility

Inclusion criteria

Inclusion criteria: 1. Primary Osteoporosis 2. Patients with sufficient understanding to fill the QOL Questionnaire and follow the structured exercise programme at home

Exclusion criteria

Exclusion criteria: 1. Impaired Kidney Function 2. Uncontrolled Cardiac Conditions such as Arrythmias 3. Any Neurological, Muscular or Orthopaedic condition that hinders participation in the exercise programme 4. Patients having received any medications for Osteoporosis (Other than Calcium and Vitamin D3 ) within the last 1 year

Design outcomes

Primary

Measure	Time frame
To compare the effect of a single intravenous infusion of zoledronic acid with a structured exercise program on BMD using DEXA scanning.Timepoint: 1 year	—

Secondary

Measure	Time frame
To compare the effect of a single intravenous infusion of zoledronic acid with a structured exercise program on Pain using Numeric Pain Rating Scale (NPRS) and QOL using ECOS â?? 16 Questionnaire.Timepoint: 6 months and 1 year	—

Countries

India

Contacts

Public ContactDr Abhimanyu Vasudeva

AIIMS, New Delhi

slyaiims@yahoo.co.in9560678577

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026