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Efeect of heart function (cardiac output & blood pressure) on brain Blood Flow in patients of head injury and bleeding in brain (Subarachnoid haemorrhage)

Does manipulating Cardiac Output and Blood Pressure cause associated parallel change in Cerebral Blood Flow in patients of TBI and SAH

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/03/012827
Enrollment
100
Registered
2018-03-26
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Traumatic brain injury and Aneurysm

Interventions

None listed

Sponsors

National Institute of Mental Health and Neurosciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult patients 18 - 65 years 2. Disease conditions: TBI, SAH 3. TBI: [a] patients admitted to ICU and requiring pharmacological support to manage blood pressure. [b] both operated and non-operated 4. SAH: [a] anterior circulation aneurysms-ruptured [b] operated patients [c] requiring pharmacological therapy for BP augmentation.

Exclusion criteria

Exclusion criteria: 1. Penetrating head injury 2. No expected change in Systolic blood pressure inspite of maximum dose of Norepinephrine (not to exceed 0.5mcg/kg/min in our study) 3. Poor intracranial acoustic window

Design outcomes

Primary

MeasureTime frame
To study changes in cerebral haemodynamics following augmentation of Cardiac Output and Blood Pressure in patients of Traumatic brain injury and Subarachnoid haemorrhage.Timepoint: (1)before starting noradrnaline (2) At 20% increase in systolic blood pressure (3) At 40% increase in systolic blood pressure—

Secondary

MeasureTime frame
NILTimepoint: NIL—

Countries

India

Contacts

Public ContactManjunatha L

National Institute of Mental Health and Neuro Sciences

gsuma123@yahoo.com9449026504

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026