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A Clinical Trial to Study the association between intake of Proton Pump Inhibitors and certain Cell membrane changes and its correlation with intracellular ionic dearrangements in patients who had undergone heartattack by comparing with similar patients who are not on proton pump inhibitor therapy.

Association of Proton Pump Inhibitors with Phosphatidylserine Externalization in Post Myocardial Infarction Patients - A Cross sectional Study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/03/012812
Enrollment
60
Registered
2018-03-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- 60 post myocardial infarction patients,30 of them should be on proton pump inhibitor therapy for more than three months and 30 of them not on any proton pump inhibitor therapy.

Interventions

None listed

Sponsors

SRM medical college Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Group 1-Post MI patients on PPI therapy for more than 3 months. 2. Group 2 - Post MI patients who are not on any PPI therapy.

Exclusion criteria

Exclusion criteria: 1.patient age more than 75 or less than 40 years. 2.intake of diuretics. 3.renal impairment. 4.chronic liver disease. 5.malabsorption disorders. 6.pregnant/lactating mothers. 7.malignancies 8.any psychiatric illness

Design outcomes

Primary

MeasureTime frame
Increased frequency of PS Externalisation(PSE) in patients on PPI therapyTimepoint: Blood sample will be collected from subjects only once during the study period to assess for frequency of PSE by flowcytometry.

Secondary

MeasureTime frame
Dearrangements in intraerythrocytic ionised calcium and magnesium in patients on PPITimepoint: once during study period, to be assessed by spectrometry(ICP-OES)

Countries

India

Contacts

Public ContactDr Melvin George

SRM UNIVERSITY , Kattankulathur

jrs_durai@yahoo.co.in9840279010

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026