To compare the effect of additive(dexmedetomidine) to pain reducing drug(0.25% bupivacaine) in prolonging postoperative analgesia after injecting into diseased breast in breast cancer patients undergoing breast surgeries

Comparison of modified PECS block using 0.25% bupivacaine and 0.25% bupivacaine with dexmedetomidine in modified radical mastectomies: a double blinded randomized controlled trial

Status

Recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/03/012785

Enrollment

Registered

2018-03-23

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Age group between 18 to 70 years female patients belonging to ASAPS 1 or 2 undergoing modified radical mastectomy for breast cancer

Interventions

Intervention1: Group B: PECS(I and II)block with 30ml of 0.25% bupivacaine Control Intervention1: Group BD: PECS(I and II)block with 30 ml of 0.25% bupivacaine + 1mcg/kg body weight of dexmedetomidine

Eligibility

Inclusion criteria

Inclusion criteria: 1.All female patients undergoing Modified Radical Mastectomy under general anaesthesia belonging to ASAPS 1 or 2 2.Patients aged between 18 years to 70 years 3.Patients who are alert,conscious and cooperative

Exclusion criteria

Exclusion criteria: Patientâ??s refusal History of allergy to the medications used in the study Contraindications to regional anesthesia(including coagulopathy and local infection) Prior breast surgery except for diagnostic biopsies History of treatment for a chronic pain condition and/or psychiatric disorder Pregnant women Patients in whom tumour is located at the site of needle insertion for drug injection

Design outcomes

Primary

Measure	Time frame
Requirement of rescue analgesicsTimepoint: asess patients pain intensity and analgesia satisfaction in the post-operative period at 0min,30mins,1hr,2hrs,4hrs,6hrs,8hrs,12hrs,16hrs,20hrs and 24hrs	—

Secondary

Measure	Time frame
Patient comfortTimepoint: Every 4th hrly during the first 12hrs of post-operative period;Post operative nausea and vomitingTimepoint: within 24hrs postoperative period;Sedation score(based on Ramsay Sedation Score)Timepoint: Asessed at 0hrs,2hrs,4hrs,8hrs,12hrs,16hrs,20hrs and 24hrs of post-operative period	—

Countries

India

Contacts

Public ContactAmrut KRao

Kasturba Medical college and hospital

raoamruts@gmail.com9986444044

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026