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A clinical trial to study the effects of two fluids, normal saline and albumin in patients with severe dengue fever

Albumin versus saline for fluid resuscitation in children with severe dengue: A Prospective Randomized Control Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/03/012781
Enrollment
400
Registered
2018-03-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- with severe dengue fever

Interventions

Intervention1: normal saline: Group 1 will receive Normal Saline 25 ml per kg over 2 hoours as the resuscitation and and also for ongoing fluid loses. Fluid supllementation is continued till the recov

Sponsors

Dr Suchitra Ranjit
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: patients with severe dengue in critical phase

Exclusion criteria

Exclusion criteria: Infants and children admitted to the HDU/PICU with Severe Dengue with a. Significant bleeding or drop in Hct requiring transfusion b. Need for positive pressure ventilation ( NIV or invasive ventilation) at presentation to PICU c. Co-infections: Bacterial sepsis, scrub d. Patients who were fluid resuscitated prior to arrival e. Admission in recovery phase of dengue

Design outcomes

Primary

MeasureTime frame
1. Need for rescue colloids 2. Need for ventilation (NIV/invasive ventilation) 3. Organ failure 4. Mortality Timepoint: on day 1 , 2 and 3 of admission and starting the fluid therapy

Secondary

MeasureTime frame
1. Need for diuretic/hemo-dialysis/CRRT 2. Duration of positive pressure 3. Duration of PICU, Hospital stay Timepoint: during the period of hospitalization

Countries

India

Contacts

Public ContactDr Suchitra Ranjit

Apollo Childrens Hospital

chitrasona@rediffmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026