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Vasopressors and acidosis in neonates in caesarean section during spinal anaesthesia

Comparison of effect of Phenylephrine versus Norepinephrine infusion on umbilical arterial pH and maternal blood pressure during Spinal Anaesthesia for Caesarean Delivery

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/03/012773
Enrollment
60
Registered
2018-03-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients with uncomplicated normal singleton term pregnancy scheduled for elective caesarean section under spinal anaesthesia.

Interventions

Intervention1: prophylactic infusion of norepinephrine: Role of prophylactic intravenous infusion of norepinephrine for prevention of hypotension during spinal anaesthesia for caesarean delivery Pro

Sponsors

Government Medical College and Hospital Chandigarh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: a) Patients belonging to American Society of Anaesthesiologists I & II. b) Age 18 â?? 35 years. c) Patients with uncomplicated normal singleton term pregnancy scheduled for elective caesarean section under spinal anaesthesia.

Exclusion criteria

Exclusion criteria: a) Patients with absolute / relative contra-indications for spinal anaesthesia. b) Patient with pregnancy induced hypertension. c) Patients suffering from intercurrent medical diseases (Cardiovascular, Cerebrovascular or renal). d) Patients with history of allergy to any of the study drugs. e) Patients having conditions such as oligohydroamnios, intrauterine growth restriction (IUGR) which can explain pre-existing foetal hypoxemia or neonatal acidemia. f) Patients suffering from connective tissue disorders which reduce blood flow to the placenta such as systemic lupus erythematosus. g) Patient refusal to participate in study.

Design outcomes

Primary

MeasureTime frame
Umbilical arterial blood pHTimepoint: Immediately after delivery

Secondary

MeasureTime frame
Apgar score; Umbilical vein blood pH; Maternal systolic and diastolic blood pressure; Mean arterial pressure; Maternal hypotension; Maternal heart rate; Reactive hypertension; Bolus of vasopressor; Side effects of drugTimepoint: From spinal injection to delivery after every one minute

Countries

India

Contacts

Public ContactJaskaran singh

Government Medical College and Hospital sector 32 Chandigarh

Drjassy18@gmail.com9646121664

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026