Comparison of pain relief using local anesthetic with opioid morphine or using local anesthetic with another analgesic clonidine or using local anesthetic alone in knee joint scopy followed by ligament tear reconstruction surgeries

Comparative study of analgesic efficacy of intraarticular bupivacaine+morphine and bupivacaine+clonidine with that of bupivacaine alone for arthroscopic anterior cruciate ligament reconstruction - ACLStudy

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/03/012745

Enrollment

Registered

2018-03-22

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S835- Sprain of cruciate ligament of knee

Interventions

Intervention1: 25ml of 0.25% Bupivacaine with 5mg morphine intraraticular: Local anesthetic with opioid Intervention2: 25ml of 0.25% Bupivacaine with 150mcg clonidine intraarticular: Local anesthetic

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiologists class I & II patients

Exclusion criteria

Exclusion criteria: Patients with history of allergy to any of drugs used, patients who are not consenting

Design outcomes

Primary

Measure	Time frame
To compare the total duration of analgesia (time to first request for rescue analgesia)Timepoint: To compare the total duration of analgesia (time to first request for rescue analgesia by the patient from the time of administration of intraarticular drug)	—

Secondary

Measure	Time frame
24 hour analgesic consumptionTimepoint: 24hours;Hemodynamics like heart rate, blood pressure, pulseoximetry saturation, respiratory rateTimepoint: At 2 & 4 hours after drug administration;Side effects if anyTimepoint: Over 24 hours;To compare visual analog score for patients at rest and on movement (straight leg raise)Timepoint: At 2, 4, 6, 12 & 24 hours from the time of drug administration;To compare visual analog score of patientsTimepoint: At first request for rescue analgesic	—

Measure

Time frame

24 hour analgesic consumptionTimepoint: 24hours;Hemodynamics like heart rate, blood pressure, pulseoximetry saturation, respiratory rateTimepoint: At 2 & 4 hours after drug administration;Side effects if anyTimepoint: Over 24 hours;To compare visual analog score for patients at rest and on movement (straight leg raise)Timepoint: At 2, 4, 6, 12 & 24 hours from the time of drug administration;To compare visual analog score of patientsTimepoint: At first request for rescue analgesic

—

Countries

India

Contacts

Public ContactVijayalakshmi Sivapurapu

Pondicherry Institute of Medical Sciences

prerana10@yahoo.com9442176549

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026