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Effect of addition of different drugs before layngoscopy and intubation to prevent rise in BP and heart rate in patients undergoing general anaesthesia

A study to compare the Pressor Responses to Laryngoscopy and Endotracheal Intubation with intravenous Dexmedetomidine vs Magnesium sulphate as premedicants in surgical patients under BIS monitored General Anaesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/03/012744
Enrollment
120
Registered
2018-03-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- General Surgery

Interventions

Intervention1: Intravenous premedication with dexmedetomidine and magnesium suphate: To study blunting of pressor response under BIS monitoring Control Intervention1: Slow intravenous injection of 1 u

Sponsors

SGRDIMSR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I and II Scheduled for elective surgery under GA

Exclusion criteria

Exclusion criteria: 1. ASA III and above 2. Major hepatic, renal or cardiovascular dysfunction 3. Pregnancy, PIH 4. Patients on anticoagulation therapy 5. Postural hypotension 6. Anticipated difficult airway 7. Uncontrolled hypertension and myocardial disease 8. Surgeries involving anticipated major blood losses and fluid shifts 9. Patients on sedatives other than used for study 10. Patients with drug allergies

Design outcomes

Primary

MeasureTime frame
Attenuation haemodynamic stress response to laryngoscopy and intubationTimepoint: 15 minutes after study drug infusion till 30 minutes post-intubation—

Secondary

MeasureTime frame
Propofol and muscle relaxant sparing effect of dexmedetomidine and magnesium sulphate, respectivelyTimepoint: 15 minutes after study drug infusion till whole of intraoperative period—

Countries

India

Contacts

Public ContactDr Kuljit Singh Aujla

SGRDIMSR

manjotkaur1417@gmail.com9478706278

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026