To compare two doses of tranexamic acid in reducing bleeding and transfusions in total knee arthroplasty

To compare the efficacy of tranexamic acid 10mg/kg vs 15mg/kg in reducing bleeding and transfusions in total knee arthroplasty

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/03/012728

Enrollment

Registered

2018-03-21

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA 1. ASA 2

Interventions

Intervention1: tranexamic acid 10mg/kg: Tranexamic acid 10mg/kg in 100 ml NS iv half an hour before skin incision and just before tourniquet release administered. Changes in hemodynamic parameters not

every 5 minutes for the first half an hour and then every half an hour since then. Any post operative drop in hemoglobin and transfusions if at all, in addition to hospital stay are noted.

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I and II posted for TKA Age group 40 â?? 70yrs No known hypersensitivity to Tranexamic acid No history of coagulation disorders

Exclusion criteria

Exclusion criteria: Patient refusal Bleeding disorders Preoperative haemoglobin less than 9mg/dL Preoperative blood or blood product transfusion Known allergy to tranexamic acid

Design outcomes

Primary

Measure	Time frame
reducing bleeding and transfusions in total knee arthroplastyTimepoint: Every 5 minutes for the first half an hour. Half an hourly till 6 hours post first injection.	—

Secondary

Measure	Time frame
decrease in duration of hospital stayTimepoint: discharge on post operative day 2, 3 or 4	—

Countries

India

Contacts

Public ContactDr Hima R Nambiar

Nil

shailakamath@ymail.com9845090231

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026