To study the effect of clonidine on pulse rate and blood pressure after introducing a tube into the throat during general anaesthesia

To study the effects of low dose Oral Clonidine in attenuating the haemodynamic responses to laryngoscopy and intubation

Status

Recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/03/012716

Enrollment

Registered

2018-03-21

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA PS 1 & 2 patients coming for elective surgeries requiring general anaesthesia with endo tracheal intubation

Interventions

Intervention1: Tab. Clonidine 1 microgram per kg per oral: Patients will be premedicated with 1 micro gram per kg oral clonidine tablet as with a sip of water 60 minutes prior to induction of anaesth

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients aged between 18-65 years belonging to ASA physical status 1or 2 of either gender undergoing surgical procedures under general anaesthesia requiring endotracheal intubation

Exclusion criteria

Exclusion criteria: Patients with hypertension, Ischemic heart disease, BMI >25, Patients on beta blockers Patients with known or anticipated difficult airway, Duration of Laryngoscopy >1Min More than 1 attempt at intubation, Laryngoscopic grade >2B

Design outcomes

Primary

Measure	Time frame
Oral Clonidine is expected to attenuate the hemodynamic stress response ( i.e., increse in heart rate and blood pressure) to laryngoscopy and intubation but with lesser incidence of adverse effects like bradycardia and hypotension as seen with intravenous clonidineTimepoint: Duration of laryngoscopy and intubation (from the time laryngoscope inserted till the end tidal CO2 is seen on the monitor) is noted; grade of laryngoscopy, heart rate, systolic , diastolic and mean blood pressures are noted at the time of induction, just before laryngoscopy, immediately after and, 1,3,5,15 and 30 mins after intubation are noted.	—

Measure

Time frame

Oral Clonidine is expected to attenuate the hemodynamic stress response ( i.e., increse in heart rate and blood pressure) to laryngoscopy and intubation but with lesser incidence of adverse effects like bradycardia and hypotension as seen with intravenous clonidineTimepoint: Duration of laryngoscopy and intubation (from the time laryngoscope inserted till the end tidal CO2 is seen on the monitor) is noted; grade of laryngoscopy, heart rate, systolic , diastolic and mean blood pressures are noted at the time of induction, just before laryngoscopy, immediately after and, 1,3,5,15 and 30 mins after intubation are noted.

—

Secondary

Measure	Time frame
Incidence of bradycardia and hypotensionTimepoint: heart rate, systolic , diastolic and mean blood pressures are noted at the time of induction, just before laryngoscopy, immediately after intubation, 1,3,5,15 and 30mins after intubation	—

Countries

India

Contacts

Public ContactBasavaraj Herekar

Kasturba Medical College, Manipal

basavaraj.herekar8@gmail.com9686150571

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026