Health Condition 1: null- Patients undergoing elective surgery under general anaesthesia and requiring endotracheal intubation
Conditions
Interventions
Intervention1: Nalbuphine: Patients will receive 0.2 µg/kg of nalbuphine diluted to 10 ml with 0.9% saline solution over a period of 10 minutes before induction of anaesthesia.
Control Intervention1:
Sponsors
University College of Medical Sciences and Guru Teg Bahadur Hospital Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1 Patients undergoing elective surgery under general anaesthesia and requiring endotracheal intubation 2 Patients belonging to American Society of Anesthesiologist (ASA) grade I and II 3 Patients of either gender 4 Patients between 18-60 years of age 5 Patients between 40-70 kg of weight 6 Modified Mallampati Grade I and II
Exclusion criteria
Exclusion criteria: 1 Patientâ??s refusal 2 Patients with history of allergy to opioids, difficult intubation or sleep apnea 3 Patients with history of cardiovascular, cerebral, renal, hepatic, bronchospastic or endocrine disease or psychiatric disorder. 4 Patients on anti hypertensives, hypnotic or narcotic analgesics 5 Patients with anticipated difficult airway (Modified Mallampatti grade III and IV, thyromental distance 6 Full stomach patients, pregnant and lactating females.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in heart rate (HR) and systolic blood pressure (SBP)Timepoint: Tb: Baseline in OT Td: After test drug administration over 10 minutes Tp: After propofol administration Tv: 3 minutes after vecuronium administration T0: At the time of intubation T1: 1 minute after endotracheal intubation T3: 3 minutes after endotracheal intubation T5: 5 minutes after endotracheal intubation T10: 10 minutes after endotracheal intubation T15: 15 minutes after endotracheal intubation Thereafter, every 15 minutes till the end of surgery. Upto 24 hrs | — |
Secondary
| Measure | Time frame |
|---|---|
| 1 Change in diastolic blood pressure (DBP) and mean arterial pressure (MAP) 2 Side effects of the two study drugsTimepoint: Tb: Baseline in OT Td: After test drug administration over 10 minutes Tp: After propofol administration Tv: 3 minutes after vecuronium administration T0: At the time of intubation T1: 1 minute after endotracheal intubation T3: 3 minutes after endotracheal intubation T5: 5 minutes after endotracheal intubation T10: 10 minutes after endotracheal intubation T15: 15 minutes after endotracheal intubation Thereafter, every 15 minutes till the end of surgery. Upto 24 hrs | — |
Countries
India
Contacts
Public ContactAkanksha Rathore
University College of Medical Sciences and GTB Hospital
Outcome results
None listed