Comparison of buprenorphine patch with diclofenac intramuscular injection for pain relief following upper abdominal surgery under general anesthesia

Comparative evaluation of transdermal buprenorphine versus intramuscular diclofenac as postoperative analgesic for upper abdominal surgery under general anesthesia

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/03/012694

Enrollment

Registered

2018-03-21

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Upper abdominal surgery under general anesthesia.

Interventions

Intervention1: Buprenorphine: Buprenorphine patch (20 mcg/h) - single application just before induction of anesthesia. Control Intervention1: Diclofenac: Diclofenac sodium 75 mg in 1 ml given by intra

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I or II. Posted for elective upper abdominal surgical procedure under general anesthesia with likely duration of postoperative hospital stay more than 3 days. Willing to provide written informed consent.

Exclusion criteria

Exclusion criteria: Women who are pregnant or breast feeding. Serious concomitant disease of vital organs, including the liver. Febrile patient. Impaired respiratory function. History of myasthenia gravis. History of convulsive disorders. History of delirium tremens.

Design outcomes

Primary

Measure	Time frame
Visual analog scale (VAS) score. Total rescue analgesic dose.Timepoint: Total 8 - hours 4, 8, 12, 24, 36, 48, 60 and 72.	—

Secondary

Measure	Time frame
Ramsay sedation scale (RSS) score. Heart rate. Systolic and diastolic blood pressure.Timepoint: Total 9 - Baseline (preoperative) and hours 4, 8, 12, 24, 36, 48, 60 and 72.	—

Countries

India

Contacts

Public ContactDr Sandip Roy Basunia

Midnapore Medical College

blowfans@yahoo.co.in9830148042

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 21, 2026