Health Condition 1: null- Patients With established diagnosis of thoracic PHN
Conditions
Interventions
Intervention1: Pulsed Radiofrequency lesioning of
Thoracic Paravertebral
Nerve: Pulsed Radiofrequency lesionioning of the thoracic paravertebral nerves of affected thoracic dermatome and one level abo
Sponsors
University College of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients should have a diagnosis of PHN with evident hyperalgesia and allodynia confined to mid thoracic and lower thoracic dermatomes 2. Patients of PHN should have had pain for at least 4 weeks after healing of rash 3. Pain intensity >= 5 on 10cm visual analogue scale (VAS)
Exclusion criteria
Exclusion criteria: Exclusion criteria 1. Patients with history of neurological intervention for PHN 2. Evidence of other sources of pain that may confound the diagnosis 16 3. Known history of taking Pregabalin for the treatment of PHN in past 4 weeks 4. Patients with past history of myocardial infarction, diabetes mellitus, pancreatitis and vasculitis 5. Patients with recent history of surgery 6. Patients with evidence of severe renal impairment 7. Patients with history of alcohol consumption and smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients achieving a VAS score of less than 3/10 at varying intervals following pulsed radiofrequency lesioningTimepoint: at the end of 1st week, at the end of 2nd week, at the end of 4th week, at the end of 8th week and end of 12th week. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess pain intensity, quality of life and alteration in MicroRNA-133b expression.Timepoint: at baseline and at the end of 1st week, at the end of 2nd week, at the end of 4th week, at the end of 8th week and end of 12th week | — |
Countries
India
Contacts
Public ContactAshok Kumar Saxena
University College of Medical Sciences
Outcome results
None listed