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Comparison of 2 drugs used for anaesthesia on the level of steroid hormones

Changes In Serum Cortisol Levels And Hemodynamic Responses: Comparison of Etomidate and Thiopentone for Induction of General Anaesthesia in Elective Surgeries

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/03/012634
Enrollment
64
Registered
2018-03-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Any surgery for which General Anaesthesia required

Interventions

Intervention1: Etomidate: 0.3mg/kg single dose intravenously Control Intervention1: Thiopentone sodium: 5mg/kg single dose intravenously

Sponsors

Lady Hardinge Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Undergoing surgery under General Anaesthesia 2.Duration of Surgery <2 hours

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. Anticipated difficult intubation (Mallampati grade III / IV) 3. Emergency surgical procedures 4. Patients with any systemic disease 5. H/O allergy to any drugs 6. H/O steroid therapy within last 6 months 7. Surgery lasting > 2 hours

Design outcomes

Primary

MeasureTime frame
Serum Cortisol LevelsTimepoint: 1. 0 hours- Baseline value in the morning (Preoperative) 2. 4 hours after induction 3. 24 hours after induction (Postoperative)—

Secondary

MeasureTime frame
1) Hemodynamic parameters - Heart rate (HR), systolic (SBP), diastolic (DBP) and mean arterial pressure (MAP) 2) ECG, SpO2 and EtCO2 will be continuously monitored 3) Any side effects Timepoint: 1. Before induction (baseline) 2. After induction (0 min) 3. After intubation (5 min) 4. Thereafter every 15 minutes till the end of the surgery.—

Countries

India

Contacts

Public ContactRashi Sardana

Lady Hardinge Medical College

radhikaagarwala@hotmail.com9811702063

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026