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Medicines used during anesthesia for operation, isoflurane and desflurane will be compared for their effect on liver function in patients who undergo liver operation to donate part of their liver.

Effects of Desflurane vs Isoflurane on hepatic function in hepatectomy for living related donation â?? A randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/03/012525
Enrollment
70
Registered
2018-03-13
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Healthy individuals undergoing liver resection for the sake of live related liver donation

Interventions

Intervention1: nil: nil Control Intervention1: Desflurane: Route of administration -inhalational in the form of vapours along with oxygen through an endotracheal tube , dose- 5 -6 MAC(Minimum alveolar

Sponsors

Dept of Anesthesia I L B S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American society of Anesthesiologists Grade 1 and 2

Exclusion criteria

Exclusion criteria: pregnancy intraopertive blood loss > 500 ml intraoperative hypotension

Design outcomes

Primary

MeasureTime frame
Comparison of postoperative liver function tests of both groups.Timepoint: Comparison of postoperative liver function tests of both groups in post-operative days 1 2 3 5 7.—

Secondary

MeasureTime frame
Peak blood lactate levels and peak blood Aspartate Transaminase levels in the corresponding liver recipient.Timepoint: Immediate post-operative period on the day of liver transplantation.—

Countries

India

Contacts

Public ContactNandakumar K

Institute of Liver and Biliary Sciences

tandym25@gmail.com9871437478

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026