Health Condition 1: G998- Other specified disorders of nervous system in diseases classified elsewhere Health Condition 2: null- The oxidant-antioxidant equilibrium in standard treatment of tinnitus and vertigo patients.
Conditions
Interventions
Intervention1: NIL: NIL
Control Intervention1: Disease (tinnitus and/or vertigo): The goal of the study was to evaluate the oxidant-antioxidant equilibrium and inflammatory processes in patients suffe
Sponsors
Nicolaus Copernicus University Ludwik Rydygier Collegium Medicum in Bydgoszcz Poland
Ludwik Rydygier Collegium Medicum in Bydgoszcz The Chair of Medical Biology
Eligibility
Inclusion criteria
Inclusion criteria: Subject group: tinnitus patients, as well as tinnitus and vertigo patients. Control group: healthy people at the similar age and the same sex as patients. Both groups: written consent form for participation in the study
Exclusion criteria
Exclusion criteria: Exclusion criteria: other diseases, bad feeling of the studied individual on the day of the study. Moreover, the participants were not be: minor and incapacitated persons, soldiers, prisoners and persons dependent in any way from the investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Examination of patientsâ?? peripheral blood: - erythrocytic activity of superoxide dismutase, catalase and glutathione peroxidase, as well as erythrocytic concentrations of thiobarbituric acid reactive substances (TBARS) and conjugated dienes (CD) - plasma concentrations of TBARS, CD, malondialdehyde and vitamins A and E. - serum activitis of arylsulfatase, acid phosphatase, cathepsin D and alpha1-antitrypsin.Timepoint: Direct experimental material was venous blood taken from the basilic vein into two vacuum test tubes only one time for each participant (at the morning, fasting): for full blood (K2EDTA) and blood serum (clot activator and gel separator). | — |
Secondary
| Measure | Time frame |
|---|---|
| Otoneurological diagnosticsTimepoint: Single evaluation;Questionnaires: medical/otoneurological history, physiotherapic questionnaire.Timepoint: Single evaluation;Radiological tests: USG of carotid arteries, RTG of cervical spine.Timepoint: Single evaluation;Morphological and biochemical parameters of blood: blood smear and morphology, lipid profile, concentrations of C-reactive protein, thyroid hormones, glucose, testosterone, electrolytes and creatinine, as well as prothrombin time, international normalized ratio, activated partial thromboplastin time and prothrombin index.Timepoint: Single evaluation | — |
Countries
Poland
Contacts
Public ContactKatarzyna Pawlak Osinska
Nicolaus Copernicus University Ludwik Rydygier Collegium Medicum in Bydgoszcz Poland
Outcome results
None listed