Health Condition 1: null- Patients Requiring Surgical Removal of impacted third molar Under Local Anesthesia on an out patient basis will be included in the trial
Conditions
Interventions
Intervention1: Fixed Dose Combination of Trypsin , Bromelain and Rutoside: Trypsin â?? 48mg
Bromelain â?? 90mg
Rutoside â?? 100 mg
Regimen: one hour before meals every 8 hours or thrice a day
Control
Sponsors
Nair Hospital Dental College
Eligibility
Inclusion criteria
Inclusion criteria: 1. Any patient with an partially impacted mandibular third molars (upto Level B, as per the Pell and Gregory scales) and indicated for its surgical extraction. 2. Any patient who willingly gives consent for the being involved in the study 3. Healthy adult patients in the age group of 18-40 years.
Exclusion criteria
Exclusion criteria: 1. Pregnant females and Lactating mothers. 2. Patients who had/have any periapical or odontogenic lesion associated with the impacted tooth. 3. Patient known to be allergic to any constituent of the proteolytic drug combination. 4. Patients with a known allergy to co-amoxiclav group or NSAID drugs. 5. Patients with any underlying systemic condition/medication which will interfere with drug metabolism. 6. Patients on immunosuppresants. 7. Interincisal opening less than 3 cms.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain - VAS Score(Visual Analog Scale) Swelling- Analytical assessment using Facial MeasurementsTimepoint: Day 0, Postoperative Day 1, Day 5 and Day 7 | — |
Secondary
| Measure | Time frame |
|---|---|
| Mouth Opening, Day of Work Attendance, Day of Resuming Eating, Number of Rescue Medications needed, Overall DiscomfortTimepoint: Pre op Day 0, Post op Day 1, Day 5 and Day 7 | — |
Countries
India
Contacts
Public ContactTrupti Gandhewar
Nair Hospital Dental College
Outcome results
None listed