Evaluation of pretreatment with three different types of drugs in providing relief from pain and withdrawal movements on injection of an Anaesthetic drug at the time of induction

Evaluation of pretreatment with Lignocaine, Dexmedetomidine or Ketamine in providing relief from Propofol injection pain and withdrawal movements during induction of Anaesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/03/012482

Enrollment

135

Registered

2018-03-12

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients aged 18-65 years, of either sex, ASA grade I and II, BMI less than or equal to 30 kg/m2 , undergoing elective surgical procedures under general anaesthesia with endotracheal intubation.

Interventions

Intervention1: DEXMEDETOMIDINE GROUP: 0.5 mcg/kg of dexmedetomidine diluted to 2ml of isotonic saline would be administered to the patient over 10 seconds, after manual occlusion of the forearm, to en

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA grade I & II 2. BMI less than or equal to 30 kg/m2 3. undergoing elective surgical procedures under general anaesthesia with endotracheal intubation.

Exclusion criteria

Exclusion criteria: 1. History of pulmonary, renal, hepatic, endocrine, neurological or cardiovascular disease(including hypertension, those on beta blockers or digitalis),patients on any sedatives, anxiolytics or analgesics, history of drug abuse and psychiatric illness, known hypersensitivity to the study drugs. 2. Pregnant and nursing females and emergency surgical procedures. 3. Subjects with anticipated difficulty in venous access.

Design outcomes

Primary

Measure	Time frame
To study the degree of alleviation of pain and withdrawal movements, with propofol injection during induction of anaesthesia, using lignocaine, dexmedetomidine or ketamine as pretreatment.Timepoint: At the time of induction.	—

Secondary

Measure	Time frame
To study the variations in haemodynamic parameters.Timepoint: At the time of induction, preintubation , intubation and post intubation.	—

Countries

India

Contacts

Public ContactDR Karishma Batra

Vardhaman Mahavir Medical College and Safdarjung Hospital

pavannayar1957@gmail.com9971935269

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026