Health Condition 1: null- Operable stage IV squamous cell carcinoma of buccal mucosa patients planned for surgery who have not received any prior treatment.
Conditions
Interventions
Intervention1: Trans-Resveratrol (Trade name
â?? TransMaxTR) and Copper
(Trade name â?? Chelated
Copper): Trans-Resveratrol is available as a health supplement in capsule form (500mg) and is approved
Sponsors
TMC Research Administrative Council
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male or female patients 18 years and above. 2. Patients who have given written informed consent 3. Patients with performance status of 0,1 or 2 (ECOG scale) 4. Treatment naïve operable stage IV squamous cell carcinoma of buccal mucosa patients planned for surgery.
Exclusion criteria
Exclusion criteria: Medical comorbidities like hypertensive, diabetes mellitus, HbsAg and HIV positive, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the effect of R-Cu on serum and tumour tissue levels of inflammatory cytokines and circulating chromatin at pre-defined time points in patients with operable stage IV squamous cell carcinoma of buccal mucosa prior to surgery.Timepoint: 2 weeks prior to surgery (Day 0) and then after 7 days (Day 7) and then after 14 days (Day 14). | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicableTimepoint: Not applicable | — |
Countries
India
Contacts
Public ContactProfessor Dr Indraneel Mittra
Tata Memorial Centre
Outcome results
None listed