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Effect of positive end-expiratory pressure and end-tidal carbon dioxide on intracranial pressure measured indirectly through optic nerve sheath diameter.

A study to evaluate the effect of positive end-expiratory pressure (PEEP) and end-tidal carbon dioxide on optic nerve sheath diameter (ONSD) as an indirect predictor of intracranial pressure (ICP) in patients undergoing surgery under general anesthesia.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/03/012450
Enrollment
50
Registered
2018-03-09
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA 1 and 2 patients posted for elective surgery under general anaesthesia

Interventions

Intervention1: PEEP and ETCO2: Different levels of PEEP and ETCO2 applied and the change in ONSD measured ultrasonographically. Intervention2: PEEP and ETCO2: Different levels of PEEP and ETCO2 applie

Sponsors

Department of anaesthesiology and critical care Pt BD Sharma PGIMS UHS Rohtak
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and 2 patients undergoing elective surgery under general anesthesia

Exclusion criteria

Exclusion criteria: patients having orbital tumors hyperthyroidism optic neuritis pregnancy and lactaion glaucoma abnormal liver functions respiratory dysfunctions central nervous system dysfunction hypotension were excluded

Design outcomes

Primary

MeasureTime frame
EVALUATION OF THE EFFECT OF POSITIVE END-EXPIRATORY PRESSURE AND END-TIDAL CARBON DIOXIDE ON OPTIC NERVE SHEATH DIAMETER AS AN INDIRECT PREDICTOR OF INTRACRANIAL PRESSURE.Timepoint: The parameters will be recorded 5 minutes after PEEP settings at 0, 8,12,15 cm H2O with EtCO2 between 38-42 mmHg and also after 5 min of EtCO2 settings 35-37, 32-34, 29-31 mmHg with PEEP zero.—

Secondary

MeasureTime frame
Systolic blood pressure , diastolic blood pressure, Mean arterial pressure, heart rate and SpO2 will be noted. Timepoint: Systolic blood pressure , diastolic blood pressure, mean arterial pressure, heart rate and SpO2 will be recorded at baseline, after induction, after intubation, 5 minutes after PEEP settings at 0, 8,12,15 cm H2O with EtCO2 between 38-42 mmHg and also after 5 min of EtCO2 settings 35-37, 32-34, 29-31 mmHg with PEEP zero.—

Countries

India

Contacts

Public ContactDr Rajesh Kumar
drrajeshdochania653@gmail.com9050844939

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026