Health Condition 1: null- Carcinoma Oral Cavity Stage IV A and IV B fit for palliative treatment
Conditions
Interventions
Intervention1: Hypofractionated Palliative Radiotherapy: Hypofractionated Radiotherapy(5250 cGy/15 fractions) will be given for patients with late stage Oral cavity cancer ( Stage IVA and IV B) and th
Sponsors
Jawaharlal Institue of Postgraduate Medical Education and research
Eligibility
Inclusion criteria
Inclusion criteria: i)Biopsy proven Squamous cell carcinoma ii)Surgically unresectable stage IVB oral cavity cancer where oral cavity is defined as consisting of lip, alveolus, floor of mouth, hard palate, retromolar trigone, buccal mucosa and tongue (extension to infratemporal fossa extension,masticator space, pterygoid plates, or skull bases or encases internal carotid artery ) iii)Stage IVA disease- not fit for surgery/ curative treatment iv)Stage IVC disease-for palliation of local symptoms v)No previous history of radiotherapy/chemotherapy/surgery vi)No previous history of cancer
Exclusion criteria
Exclusion criteria: i)Patients with another primary at a different site ii)Pregnant women iii)Age 80 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the effect of hypofractionated palliative radiotherapy on quality of life in patients with late stage oral cavity cancer with the EORTC H&N 35 questionnaire with specific attention to pain,swallowing and mouth opening sub scalesTimepoint: 2 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Compliance to the treatment regimenTimepoint: 6 months;Acute toxicity during radiation therapy â?? using RTOG/CTCAE grading.Timepoint: 2 months;Assessment of general quality of life as per the QLQ C30 and other parameters in the H&N 35Timepoint: 2 months ;Late toxicity using RTOG/CTCAE grading14Timepoint: 6 months;Median survivalTimepoint: 6 months;The response rates as assessed by the RECIST guidelines 1.1-complete, partial, overall response ratesTimepoint: 2 months | — |
Countries
India
Contacts
Public ContactDr Aswin Chandran V
Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)
Outcome results
None listed