Health Condition 1: null- ASA grade 1 and 2. Health Condition 2: K802- Calculus of gallbladder without cholecystitis
Conditions
Interventions
Intervention1: oral premedication.: Group B: Patients received Gabapentin 800 mg in the form of two capsules containing 400 mg of Gabapentin, each orally with sips of water as premedication 2 hours pr
Sponsors
Bhupinder Singh
Eligibility
Inclusion criteria
Inclusion criteria: 1) ASA Grade I & II adult patients. 2) Patients aged 18 to 60 yrs. 3) Patients undergoing elective laparoscopic cholecystectomy under general anaesthesia.
Exclusion criteria
Exclusion criteria: 1. Patient with anticipated difficult intubation. 2. Patient with ASA III or greater. 3. Patient with cardiac, pulmonary or renal disease. 4. Patient with obesity (BMI >30) 5. Patient who are sensitive to any drugs involved in the study. 6. Patient who are on antihypertensives, sedatives, hypnotics. 7. Patient who require second attempt for intubation. 8. Patient who require duration of laryngoscopy exceeding 20 sec. 9. Pregnant and lactating women. 10. Patients who require intubation other than orotracheal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study and compare attenuation of hemodynamic responses to laryngoscopy and pneumoperitoneum during laparoscopy between oral Gabapentin and oral Pregabalin.Timepoint: I) Heart rate, Non invasive systolic, diastolic, mean arterial blood pressure, were recorded firstly at baseline (before premedication), before induction (after premedication on coming to operation theatre after 2hrs), just after laryngoscopy and intubation, and at T0, T1, T3, T5 and T10 minutes. Secondly, before pneumo peritoneum, just after pneumo peritoneum atT0, T5, T10, T15 and T30 minutes and after the release of pneumoperitoneum at T0, T5, T10 and T15 minutes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Observation of any adverse effects due to oral Gabapentin 800mg and oral Pregabalin 150mg.Timepoint: Post operative adverse effects such as nausea and vomiting, respiratory depression, dizziness, somnolence, blurred vision, headache, pruritis, peripheral oedema and diplopia were noticed; upto 6 hours in post operative period. ;Recovery charaterstics of patients.Timepoint: Recovery charaterstics of patients were recorded till 4hours in post operative period using modified alderete scoring system.;To study and compare preoperative and postoperative sedation level of oral Gabapentin 800mg and of oral Pregabalin150mg. Timepoint: Level of sedation of the patients was monitored every 30 minutes, 1½ hours prior to surgery using Ramsay sedation scale and post operatively every 15 min for 2 hours and every 30 min for next 4 hrs. | — |
Countries
India
Contacts
Public ContactDr Bhupinder Singh
Satguru Partap Singh Hospitals
Outcome results
None listed