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Effect of a single preoperative glucocorticosteroid injection on inflammatory response following thryoidectomy

A study on the effect of preoperative dexamethasone on systemic inflammatory response in patients undergoing thyroidectomy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/03/012419
Enrollment
60
Registered
2018-03-07
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients undergoing surgery for thyroid disease.

Interventions

Intervention1: Dexamethasone: A single injection of 8mg (2ml) Dexamethasone given intravenously before induction of anaesthesia Control Intervention1: Normal saline: A single injection of 2 ml Normal

Sponsors

Jawaharlal Nehru Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with symptomatic thyroid disease who were candidates for thyroidectomy

Exclusion criteria

Exclusion criteria: Patients having any of the following: 1. American Society of Anesthesiologists (ASA) physical class III or IV. 2. Age more than 75 years. 3. Pregnancy. 4. Intake of corticosteroids within past 4 weeks 5. Coagulation disorders. 6. Cushing disease. 7. Uncontrolled diabetes mellitus. 8. Severe hepatic impairment. 9. Renal impairment. 10. Systemic Tuberculosis. 11. Osteoporosis. 12. Immunocompromised states. 13. Pre- existing wide angle glaucoma 14. Severe systemic bacterial, viral or fungal infections. 15. Patients with preoperative deranged cell counts, C reactive protein levels or cytokine profile

Design outcomes

Primary

MeasureTime frame
Peri-operative changes in: 1.Levels of pro-inflammatory cytokines (TNFα, IL-1β and IL-6) and anti-inflammatory cytokine (IL-10) 2.Leukocyte count 3.C-Reactive ProteinTimepoint: At 6 hours and 24 hours post thyroidectomy—

Secondary

MeasureTime frame
NILTimepoint: N/A—

Countries

India

Contacts

Public ContactDr Saurabh Varshney

Jawaharlal Nehru Medical College, A.M.U, Aligarh

drazrab@yahoo.in

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026