Health Condition 1: null- Patients belonging to the American Society of Anesthesiologists (ASA) physical status Grade I and II, age 15- 45 years of either gender and surgery requiring general anaesthesia
Conditions
Interventions
Intervention1: Melatonin: Oral melatonin tablet 6 mg (two tablets of 3 mg each), administered 120 min before surgery
Control Intervention1: Placebo: Vitamin D3 tablet (2 tablets), administered 120 min
Sponsors
King Georges Medical University
Eligibility
Inclusion criteria
Inclusion criteria: Patients belonging to the American Society of Anesthesiologists (ASA) physical status Grade I and II. Age 15- 45 years of either gender. Surgery requiring general anaesthesia for duration longer than 30 min
Exclusion criteria
Exclusion criteria: Patients with history of diabetes, hypertension, psychiatric illness, intake of antipsychotics, sedatives, anxiolytics and antiepileptic drugs, sleep disorders, obesity and drug allergy. Patients with anticipated difficult intubation and those requiring more than one attempt or more than 20 s for laryngoscopy will be excluded from the study. The pregnant and lactating females will also be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Premedication with 6 mg melatonin administered orally 120 min before induction of anaesthesia is effective for providing haemodynamic stability at the time of laryngoscopy and intubation during induction of general anaethesia. Melatonin reduces the dose of propofol required for induction of anaesthesia. Timepoint: ONE YEAR | — |
Secondary
| Measure | Time frame |
|---|---|
| Melatonin reduces the dose of propofol required for induction of anaesthesia. Timepoint: ONE YEAR | — |
Countries
India
Contacts
Public ContactV K Bhatia
King Georges Medical University Lucknow
Outcome results
None listed