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Zoledronic acid injection prevents bone loss in spinal cord injury patients

Effect of early treatment with Zoledronic acid in prevention of bone loss in spinal cord injury patients: a randomized prospective interventional study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/03/012408
Enrollment
60
Registered
2018-03-07
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Spinal cord injury with neurological deficit

Interventions

Intervention1: Zoledronic acid: 5mg in 100ml infusion is given at baseline after patient is medically and surgically stabilised and baseline bone mineral density scan has been taken. Control Intervent

Sponsors

Dr Satyaranjan Sethi
Lead Sponsor
Dr Sunil Goenka
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1. SCI patients 2. ASIA Impairment Scale A,B,C 3. Age over 18years 4. Less than 3months from date of trauma

Exclusion criteria

Exclusion criteria: 1. Hypocalcaemia (Serum Calcium 2. Vitamin-D deficiency (Serum 25-hydroxy vitamin-D 3. Significant renal impairment (Creatinine clearance 4. Any history of allergic reaction to bisphosphonates 5. History of iritis, uveitis, psychiatric illness 6. Female subjects who are pregnant, lactating or premenopausal women planning to conceive

Design outcomes

Primary

MeasureTime frame
To assess magnitude of bone loss at hip and forearm following Spinal cord injury by bone mineral density by DEXA scanTimepoint: Baseline at entry into study, 3 months, 6 months and 12 months follow up—

Secondary

MeasureTime frame
To study the effect of early administration of Zoledronic acid on prevention of bone loss at hip and forearm in Spinal cord injuryTimepoint: Baseline, 3 months, 6 months and 12 months—

Countries

India

Contacts

Public ContactDr Sunil Goenka

S.M.S. Medical College, Jaipur

dr_goenka@yahoo.com9314969696

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026