Health Condition 1: null- Children suffering from empyema thoracic Health Condition 2: J90- Pleural effusion, not elsewhere classified
Conditions
Interventions
Intervention1: Video assisted Thoracoscopic Surgery for Empyema: This is the standard of care for children with stage II empyema in children
Control Intervention1: Urokinase: This will be instilled th
Sponsors
Centre for advance Research Rajiv Gandhi University of Health Sciences Karnataka
Eligibility
Inclusion criteria
Inclusion criteria: 1.Diagnosis of Empyema with pleural fluid showing a)Frank pus appearance or b)organisms in grams stain and 2.Evidence of septations or loculations and pleural thickening on chest X-ray and Ultrasound thorax.
Exclusion criteria
Exclusion criteria: 1.Resolution of Empyema with initial intercostal drainage 2.Previous history of hypersensitivity to fibrinolytics 3.Complicated pneumonia (Organized empyema with thick peel, lung abscess, Necrotizing pneumonia, Bronchopleural fistula) 4.Bleeding diathesis 5.Immunocompromized status 6.Associated major co-morbid condition/s as determined by clinician 7.Air leak after ICD insertion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of each therapy Treatment efficacy of each arm of study in terms of duration for clinical recovery, ICD days, analgesia requirement, and intensive care requirements. Cost analysis Length of hospital stay Timepoint: Immediate post therapy 30 days 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Microbiology of pleural fluid- yield and incidence of organisms Long term complications Determination of criteria for CT scan Antibiotic guidelines to institute for management of empyema Primary role of chest tube drainage only for empyema management. Need for blood transfusion Timepoint: 30 days | — |
Countries
India
Contacts
Public ContactDr Gowri Shankar
Indira Gandhi Institute of Child Health Bangalore
Outcome results
None listed