Health Condition 1: null- Sepsis
Conditions
Interventions
Intervention1: Ringer Lactate: It is a balanced Crystalloid. Volume resuscitation would be done according to recommendations provided in surviving sepsis campaign guideline-2016. Initially patie
Sponsors
Postgraduate Institute of Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients with age 18 years or more 2.Having increase in sequential organ failure assessment (SOFA) score of 2 points or more along-with documented source of infection anywhere in body proven either clinically or by laboratory/radiological investigation/s 3.Who give consent for participation in the study, are eligible for inclusion in the study
Exclusion criteria
Exclusion criteria: 1. Patients less than 18 years; 2. Pregnancy 3. Patients on admission having baseline elevated chloride and potassium levels 4. Patients who are already diagnosed with Chronic Kidney or Liver disease 5. Patients who have already received initial fluid resuscitation before reporting to emergency medical services for a period exceeding 24 hours 6. Patients receiving or expected to receive RRT within 6 hours 7. Patients who are on maintenance hemodialysis for Chronic Kidney disease 8. Patients having component of concurrent cardiogenic shock 9. Not willing to give written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To find out incidence of hyperchloremia at 24 hours from the time of randomization and during hospital stay in adult patients with confirmed diagnosis of sepsis presenting in emergency medical services receiving either Normal saline or Ringerâ??s Lactate for fluid resuscitation during first 24 hours post randomizationTimepoint: At 24 hours from the time of randomization and at time of discharge | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objectives are to ascertain: â?¢Incidence of AKI at 24 hours, 48 hours from the time of randomization and during their hospital stay â?¢Change in pH from baseline to 6, 12, 24, 48 hours after randomization and lowest pH documented during their hospital stay â?¢Change in coagulation parameters from baseline to 24, 48 hours after randomization and worst parameters documented during their hospital stay â?¢Hospital mortality and 30 day mortality Timepoint: At 6, 12, 24, 48 hours from the time of randomization and at time of discharge | — |
Countries
India
Contacts
Public ContactDr Rithvik Golla
Postgraduate Institute of Medical Education and Research
Outcome results
None listed