Benefits and harms of using moderately high dose Turmacin, an active ingrediant of turmeric on acute joint pain in healthy volunteers

Tolerability and efficacy of moderately high dose Turmacin supplementation on joint discomfort among healthy volunteers â?? open label single arm pilot study

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/03/012367

Enrollment

Registered

2018-03-06

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Turmacin 2g: Turmacin 2g capsule once daily orally for 7 days Control Intervention1: Not applicable: Not applicable

Eligibility

Inclusion criteria

Inclusion criteria: 1.All consenting adults aged between 18 and 65 years judged by Investigator to be in general good health on the basis of medical history 2.No knee joint discomfort/pain at rest; 3.Must achieve a knee joint discomfort/pain score of at least >= 40 mm on visual analogue scale (VAS) for pain after 10 minutes of brisk walk on the stepmill equipment.

Exclusion criteria

Exclusion criteria: 1.Subjects having liver problems (raised ALT, AST), Heart (abnormal ECG / ECHO), kidney problems (raised creatinine), other muscle related problems (raised creatine kinase). 2.Subjects having neurological disorders 3.BMI greater than 32 kg/m2 4.Taking concomitant medication like pain relievers or complements/ multivitamin supplements/ phytotherapeutical products that interfere with the product or outcomes of the study. 5.Suffering from any kind of arthritic condition viz., autoimmune, infectious in the knee that could mislead the evaluation. 6.Having trauma or surgery histories that have affected the knee. 7.Having a disease that results in bad intestinal absorption 8.Women of child bearing age who do not wish to use approved birth control methods during study 9.Being pregnant or breastfeeding. 10.Allergic or hypersensitive to turmeric 11.Being participating or having participated in a clinical assay or intervention study within the previous 30 days before inclusion in the study 12.Being unable to follow the guidelines of the study

Design outcomes

Primary

Measure	Time frame
joint pain on visual analogue scale after exerciseTimepoint: days 5 and 7	—

Secondary

Measure	Time frame
adverse effectsTimepoint: days 5 and 7	—

Countries

India

Contacts

Public ContactDr Jeffrey Pradeep Raj

St. Johns Medical College, Bangalore

jpraj.m07@gmail.com8095464464

Outcome results