Effect of Turmacin - an active component from Turmeric in improving joint health among healthy volunteers

Effect of Turmacin supplementation on joint discomfort and functional outcome among healthy volunteers â?? a randomized placebo controlled trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/03/012359

Enrollment

Registered

2018-03-06

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Turmacin 0.5g: Turmacin capsule 0.5g oral once daily for 84 days Intervention2: Turmacin 1g: Turmacin 1g capsule once daily orally for 84 days Control Intervention1: Placebo: Identical

Eligibility

Inclusion criteria

Inclusion criteria: 1. All consenting adults aged between 18 and 65 years judged by Investigator to be in general good health on the basis of medical history 2.No knee joint discomfort/pain at rest; 3.Must achieve a knee joint discomfort/pain score of at least >= 40 mm on visual analogue scale (VAS) for pain after 10 minutes of brisk walk on the stepmill equipment.

Exclusion criteria

Exclusion criteria: 1.Having trauma or surgery histories that have affected the knee. 2.Having a disease that results in bad intestinal absorption 3.Women of child bearing age who do not wish to use approved birth control methods during study 4.Being pregnant or breastfeeding. 5.Allergic or hypersensitive to turmeric 6.Being participating or having participated in a clinical assay or intervention study within the previous 30 days before inclusion in the study 7.Being unable to follow the guidelines of the study 8.Subjects having liver problems (raised ALT, AST), Heart (abnormal ECG / ECHO), kidney problems (raised creatinine), other muscle related problems (raised creatine kinase). 9.Subjects having neurological disorders 10.BMI greater than 32 kg/m2 11. Taking concomitant medication like pain relievers or complements/ multivitamin supplements/ phytotherapeutical products that interfere with the product or outcomes of the study. 12.Suffering from any kind of arthritic condition viz., autoimmune, infectious in the knee that could mislead the evaluation.

Design outcomes

Primary

Measure	Time frame
Joint pain reported on visual analogue scaleTimepoint: days 5,7,28,56,84	—

Secondary

Measure	Time frame
Isokinetic strength assessed in different velocities in random orderTimepoint: Days 1 & 84;isometric and isokinetic knee extension for quadriceps and hamstrings at various angular velocity (60 degree/sec to 300 degree/sec)Timepoint: Days 1 & 84;Maximal isometric torque will be measured with knee extension from the knee flexed (90 degree) positionTimepoint: Days 1 & 84	—

Countries

India

Contacts

Public ContactDr Jeffrey Pradeep Raj

St. Johns Medical College

jpraj.m07@gmail.com8095464464

Outcome results