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Comparison of the effects of the two drugs dexmedetomidine and midazolam when given for spinal anaesthesia

Comparison of dexmedetomidine and midazolam as adjuvants to 0.75% isobaric ropivacaine spinal anaesthesia in lower limb surgeries

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/03/012353
Enrollment
88
Registered
2018-03-06
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients with major co-morbid conditions

Interventions

Intervention1: Dexmedetomidine: 10mcg dexmedetomidine is added with 0.75% ropivacaine for spinal anaesthesia Control Intervention1: Midazolam: 2mg midazolam is added to 0.75% ropivacaine for spinal an

Sponsors

Dr J Jancy
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1)Age 18-60 years. 2)American Society of Anaesthesiologists (ASA) Grade I and II.

Exclusion criteria

Exclusion criteria: 1)Patient refusal for subarachnoid block 2)Known allergy to the study drugs 3)Infection at the puncture site 4)Coagulation disorders 5)Neurological disorders 6)Hepatic and renal disorders 7)Use of antipsychotic medications 8)Body mass index >= 30kg/m2 9)Pregnancy & lactation 10)ASA >= III

Design outcomes

Primary

MeasureTime frame
Onset and duration of sensory and motor blockTimepoint: 1)Onset of motor and sensory block will be assessed every 3min for the first 15 min after spinal anaesthesia. 2) Duration of motor and sensory block will be assessed at the end of surgery in the post operative period.

Secondary

MeasureTime frame
Haemodynamic stability Duration of analgesiaTimepoint: During the course of surgery At the end of 24hr

Countries

India

Contacts

Public ContactDr Tejesh C A

Ramaiah Medical College

drtejeshca@yahoo.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026