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Comparison of effectiveness of two different regimen of antibiotic and placebo on complication related to impacted third molar surgery

Use of Antimicrobials in Impacted Mandibular Third Molar Surgery: A Prospective, Randomized, Double Blind Placebo Controlled Clinical Trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/03/012332
Enrollment
75
Registered
2018-03-05
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- IMPACTED MANDIBULAR THIRD MOLARS

Interventions

Intervention1: Group-2(Prophylaxis group): Preoperative(before surgery) Active Antibiotic given- Amoxicillin-2gram and metronidazole 1gram 1 hour before surgery, Postoperatively-placebo capsule si

Sponsors

Panjab university chandigarh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA score 1 2. Patient requiring surgical removal of third molar mesioangular impaction with difficulty index described by Pederson as moderate and will be measured from panoramic radiograph 3. Patient agreement to surgical procedure and clinical trial, providing informed consent 4. Patient not under antibiotics for the past 30 days

Exclusion criteria

Exclusion criteria: 1. The patient has a systemic illness which contradicts the surgery on patients 2. Immunosuppressive treatment 3. Smoking 4. Peptic ulcer 5. Alcoholic 6. Pregnant women or women who were lactating 7. Previously radiated maxillofacial region 8. Patients with difficulties in completing the study or who will not sign the consent form 9. Known or suspected to be allergic to anti-inflammatory drugs or antibiotics 10. Carious or nonimpacted third molars 11. Those with signs of pericoronitis and 12. Those in whom excessive technical difficulty will be expected.

Design outcomes

Primary

MeasureTime frame
infection and inflammatory parametersTimepoint: infection and inflammatory(pain, maximum mouth opening,body temperature,swelling on face, dysphagia) parameters will be checked on 1st 3rd 7th and 30th days

Secondary

MeasureTime frame
InfectionTimepoint: Will be checked on 1st 3rd 7th and 30th days

Countries

India

Contacts

Public ContactDr Sunil Kumar Beniwal

Panjab University

hemant_batra69@yahoo.com9814555550

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026