EFFECT OF BOLUS AND INFUSION DOSE OF PHENYLEPHRINE TO PREVENT FALL IN BLOOD PRESSURE AFTER SPINAL ANAESTHESIA

STUDY COMPARING PHENYLEPHRINE BOLUS AND INFUSION FOR MAINTAINING ARTERIAL BLOOD PRESSURE DURING CAESAREAN SECTION UNDER SPINAL ANAESTHESIA

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/03/012286

Enrollment

100

Registered

2018-03-01

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Pregnant patients of physical status ASA I and II scheduled to undergo caesarean section

Interventions

Intervention1: Injection Phenylephrine: In group A bolus dose of phenylephrine (50 mcg) was given in patients who developed hypotension i.e, fall in SBP â?¥ 20% of basal value. â?¢ In group B, we star

Eligibility

Inclusion criteria

Inclusion criteria: a)Full term pregnant patients undergoing elective/emergency caesarean section under sub-arachnoid block b) ASA Grade I & II c) Patients giving informed, written and valid consent. d) Height between 150 to 168 cm.

Exclusion criteria

Exclusion criteria: a) Patient refusal for the procedure b) Patients with significant coagulopathies and other contra-indications for spinal anaesthesia. c) Patient with pregnancy induced hypertension d) Patients with history of significant systemic disorders (cardiovascular, respiratory or central nervous system). e) Fetal distress

Design outcomes

Primary

Measure	Time frame
After using the bolus and infusion dose of Phenylephrine in two different groups ( bolus and infusion group) blood pressure was more tightly controlled in the infusion group compared to the therapeutic bolus dose of phenylephine. None of the patients developed reactive hypertension. The maternal side effects like bradycardia was not observed and intra operative nausea and vomiting was similar. The APGAR scores and fetal acid base status did not show any difference in the two groups.Timepoint: 2 minutes	—

Measure

Time frame

After using the bolus and infusion dose of Phenylephrine in two different groups ( bolus and infusion group) blood pressure was more tightly controlled in the infusion group compared to the therapeutic bolus dose of phenylephine. None of the patients developed reactive hypertension. The maternal side effects like bradycardia was not observed and intra operative nausea and vomiting was similar. The APGAR scores and fetal acid base status did not show any difference in the two groups.Timepoint: 2 minutes

—

Secondary

Measure	Time frame
No secondary out comeTimepoint: 0	—

Countries

India

Contacts

Public ContactDR MANISH

Vardhman Mahavir Medical College and Safdarjung Hospital

jeetendrabajaj@gmail.com9810465070

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026