Health Condition 1: null- Medication non responsive obsessive compulsive disorder
Conditions
Interventions
Intervention1: Active Repetitive transcranial magnetic stimulation(rTMS): Low frequency rTMS will be delivered at 1 Hz at 110% of resting motor threshold for a train duration of 10secs using a figure-
Sponsors
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1-Age 18-65 years. 2- Either Gender. 3-Meeting DSM 5 criteria for OCD (American Psychiatric Association, 2013). 4-Right handed (assessed by Edinburghâ??s Handedness Inventory). 5-Willing to give written informed consent for participation in the study. 6-Meeting criteria for medication non-response as per ITROC (level 3 non-response) defined by non-response to adequate trial of two SSRI medications given in optimum dosage for a period of at least 12 weeks. 7-YBOCS score >=16 (i.e. Moderate Severity).
Exclusion criteria
Exclusion criteria: 1-Presence of any other psychiatric disorder or substance use disorder (except caffeine or nicotine) through M.I.N.I 7.0. screening. 2-History of seizure. 3-History of receiving any treatment with brain stimulation. 4- Known or suspected pregnancy or currently lactating. 5-Presence of unstable medical illness. 6-History suggestive of space occupying brain lesion or cerebro-vascular accident. 7-Having implanted device or metal in brain/head or cardiac pacemaker or ferromagnetic dental braces.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in YBOCS csoreTimepoint: Baseline assessment will be done within a week prior to initiating rTMS. Assessment will be repeated within 24 hours at end of 5th session, last session and 4 weeks following the last session. | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in CGI scoresTimepoint: Baseline assessment will be done within a week prior to initiating rTMS. Assessment will be repeated within 24 hours at end of 5th session, last session and 4 weeks following the last session. | — |
Countries
India
Contacts
Public ContactDr Ankita Chattopadhyay
AIIMS New Delhi
Outcome results
None listed