Health Condition 1: null- 1. ASA grade I or II undergoing neurosurgery under general anesthesia. 2. On chronic (7 days) phenytoin or levetiracetam therapy.
Conditions
Interventions
Intervention1: levetiracetam: effect on neuromuscular blockade following vecuronium or atracurium at maintainance dose (one-fourth of ED95) to maintain ToF count 0 for neurosurgical proceedures
Contro
Sponsors
SCTIMST Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. ASA grade I or II undergoing neurosurgery under general anesthesia. 2. Age 18-60 years, of either sex, who have the ability to give informed consent. 3. On chronic ( >7 days) phenytoin or levetiracetam therapy
Exclusion criteria
Exclusion criteria: 1. Pre-existing neuromuscular disease 2. Prolonged administration of neuromuscular blocker 3. Any other drug known to affect neuromuscular function 4. Peripheral neuropathies 5. Prolonged immobility 6. Following major burns upto 2 years 7. Liver disease 8. Kidney disease 9. Cardiac disease 10. Pregnancy 11. Pre-existing or intraoperative acid-base disorder 12. Electrolyte imbalances such as hyper/hypokalemia, hyper/hypocalcemia, hyper/hypomagnesemia, hyper/hyponatremia 13. Endocrinopathies 14. Patient refusal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of effectiveness of supplemental doses of muscle relaxant is considered to be the primary outcome of this study and will be described as mean and standard deviationTimepoint: After completion of sample size | — |
Secondary
| Measure | Time frame |
|---|---|
| time duration needed to achieve Train of Four (ToF) count zero after first bolus dose of muscle relaxant, time duration needed to achieve Train of Four (ToF) ratio â?¥ 0.90 after bolus dose of reversal agents (neostigmine)Timepoint: After completion of sample size | — |
Countries
India
Contacts
Public ContactManikandan S
Sree Chitra Tirunal Institute for Medical Sciences and Technology
Outcome results
None listed