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Comparison of cost benefits and environmental effects of various agents called Isoflurane,Desflurane and Nitrous oxide which are used for making the patient unconscious during surgery

Safety, economic and environmental impact of desflurane in minimal flow anaesthesia (0.5l/min) with or without nitrous oxide, compared to isoflurane-air-oxygen used with low flow (1l/min) - a randomized open labelled single blinded study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/02/012181
Enrollment
90
Registered
2018-02-27
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C55- Malignant neoplasm of uterus, partunspecified Health Condition 2: null- Patients aged 25-65 years of ASA I-II posted for elective laparotomy lasting for more than 90 minutes using general anaesthesia

Interventions

Intervention1: Usage of isoflurane with air in low flow (1 lit/min) and desflurane with air or nitrous oxide in minimal flow (0.5 lit/min): Compare the safety, economic and environmental impact of des

Sponsors

AIIMS New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I-II patients posted for elective laparotomy lasting for more than 90 minutes

Exclusion criteria

Exclusion criteria: 1.Patient refusal to participate 2.Pregnant patients 3.Laparoscopic surgery 4.BMI more than or equal to 35 kg/m2 5.Patients already in ICU 6.Conditions precluding use of neuraxial anaesthesia 7.Anaesthesia workstation with more than acceptable leak

Design outcomes

Primary

MeasureTime frame
Calculate ml/hour and cost/hour of anaesthetic with each of the following combinations: 1.Desflurane in combination with N2O, O2 : FGF of 500 ml/min, End-Tidal concentration 5-6%. 2.Desflurane in combination with Air, O2: FGF of 500 ml/min, End-Tidal concentration 5-6%. 3.Isoflurane with Air, O2 with FGF 1 l/min, End-Tidal concentration 1%. Timepoint: Time taken for surgery—

Secondary

MeasureTime frame
1.Intra operative PaO2 in all groups 2.Incidence of Post operative Nausea and vomiting (PONV) in all the groups Timepoint: Time taken for surgery—

Countries

India

Contacts

Public ContactDr Bokinala Naveen

AIIMS, New Delhi

drsrajeshwari@gmail.com9868397810

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026