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In controlled hypertensive patients undergoing elective surgery, which of the three agents- propofol, thiopentone and etomidate (all the three are intravenous anaesthetic induction agents) , results in the most haemodynamically stable conditions during anaesthetic induction and intubation ?

Comparison of haemodynamic response to anaesthetic induction and intubation with Propofol, Thiopentone and Etomidate in controlled hypertensives undergoing elective surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/02/012154
Enrollment
120
Registered
2018-02-26
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I10- Essential (primary) hypertension

Interventions

Control Intervention1: PROPOFOL, THIOPENTONE, ETOMIDATE: INTRAVENOUS INDUCTION ANAESTHETIC DRUGS

Sponsors

VMMC and Safdarjung Hospital Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult ASA Physical status 2 patients, of either sex, scheduled for elective surgery, on regular and compliant anti-hypertensive treatment, labelled as controlled with not a single BP reading of >140/90 mm Hg within the past 7 days.

Exclusion criteria

Exclusion criteria: 1. Co-morbid conditions like diabetes, epilepsy, chronic obstructive pulmonary disease, known adrenal insufficiency, obstetric, cervical spine surgery patients, a history of MI/ stroke/ renal failure. 2. Known sensitivity to propofol/ thiopentone/ etomidate/ opioids/ barbiturates/ egg/ soyabean and history of use of propofol/ thiopental/ etomidate within 1 week pre-operatively. 3. Anticipated difficult airway ( Modified Mallampati Grade III and IV ) and obese patients who have BMI of and above 30 kg/metre2.

Design outcomes

Primary

MeasureTime frame
Haemodynamic parameters of  1.Heart Rate (HR)  2.Non Invasive Blood pressure measurements- Systolic (SBP), Diastolic (DBP) and Mean arterial pressure (MAP) and  3.Any ECG abnormalities/changes in lead II and V5Timepoint: 1.Baseline (SI), 2.Post- fentanyl (SII), 3.At Induction (I), 4.Post Induction at 1 minute (I1) and at 3 minutes (I3), 5.At Laryngoscopy and Intubation (T) and 6.Post Intubation at 1 minute (T1) , 3 minutes (T3), 5 minutes (T5), 7 minutes (T7) and 10 minutes (T10).—

Secondary

MeasureTime frame
Any incidence of  pain on injection, muscle twitching, hypotension, hypertension, arrhythmias, apnoea or hiccups .Timepoint: At any time point of 1.Baseline (SI), 2.Post- fentanyl (SII), 3.At Induction (I), 4.Post Induction at 1 minute (I1) and at 3 minutes (I3), 5.At Laryngoscopy and Intubation (T) and 6.Post Intubation at 1 minute (T1) , 3 minutes (T3), 5 minutes (T5), 7 minutes (T7) and 10 minutes (T10).—

Countries

India

Contacts

Public ContactDR Priyanka

VMMC and Safdarjung Hospital, Delhi

nupur4@hotmail.com9013201891

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026