Comparing the effect of propofol and sevoflurane as anaesthetic agent on cerebral oxygenation using SjVO2 as parameter and effect on levels of IL-6 in patient undergoing surgery for traumatic brain injury.

Comparing the effect of intravenous (propofol) and inhalational (sevoflurane) anaesthetic agent on cerebral oxygenation using SjVO2 as parameter in patient undergoing surgery for traumatic brain injury.

Status

Active, not recruiting

Phases

Phase 1

Study type

Observational

Source

CTRI

Registry ID

CTRI/2018/02/012139

Enrollment

Registered

2018-02-26

Start date

Unknown

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G00-G99- Diseases of the nervous system Health Condition 2: null- Head Injury patients

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with Isolated brain injury 2. Patients who had operable Acute Subdural Hematoma (SDH), brain contusion or both 3. ASA IE-IIE patients

Exclusion criteria

Exclusion criteria: (1) Patients with motor response (2) Patients in shock (SBP induction of anaesthesia. (3) Any comorbidity other than hypertension or diabetes (i.e. Coronary artery disease, COPD, Hepatic or Renal impairment). (4) Patients who had polytrauma.

Design outcomes

Primary

Measure	Time frame
Cerebral oxygenation using jugular venous oxygenationTimepoint: Start of Surgery, End of Surgery and 12 hours after Surgery	—

Secondary

Measure	Time frame
Intraoperative hemodynamic parameters and brain relaxation. Levels of serum Inflammatory biomarker Interleukin-6Timepoint: Start of Surgery, End of Surgery and 12 hours after surgery.	—

Countries

India

Contacts

Public ContactDr Rajeev Chauhan

MD Anaesthesia and Intensive Care, PGI Chandigarh.

dr.rajeevchauhan@gmail.com7087422950

Outcome results