Health Condition 1: null- Malaria Patients(P vivax and P falciparum) Non malaria patients Healthy volunteers
Conditions
Interventions
Intervention1: B cell phenotyping: Through this hypothesis generating study we hope to establish if there is a disturbance in the peripheral B cell subsets of patients suffering an acute episode of vi
Sponsors
Tata Institute of Fundamental Research
Eligibility
Inclusion criteria
Inclusion criteria: Females and males of age 5 and above and upto the age of 70 years with clinically suspected malaria on treatment with antimalarials and/or uncomplicated symptomatic malaria (proven) as indicated by the presence of blood smears positive for P falciparum or P. vivax asexual parastemia Participants (living/working with the malaria patients) of either gender with age more than 18 and upto a maximum of 70 years Participants of either gender with age more than 18 (upto a maximum of 70 yers) and suffering from non- malarial fever Willing to participate in this study and ability to comply with the study protocol
Exclusion criteria
Exclusion criteria: Inability to comprehend or unwillingness to follow the study protocol. Complicated malaria patients ( patients with cerebral malaria multiple organ dysfunction severe anemia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of B cell subsets TLR4 expression and antiparasite antibody profiles on day 1 (main) and day 30 (preferably)Timepoint: Blood collection will be done on Day 1 and Day 30 | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactDr Nithya Gogtay
Department of Clinical Pharmacology GSMC and KEM hospital
Outcome results
None listed