Dose response on brain activity by low level light therapy of brain

Dose Response Relationship between Near Infrared (NIR) Light Stimulation and Functional Brain Activity

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/02/012075

Enrollment

Registered

2018-02-22

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Light therapy- Near Infrared: Transcranial: 633nm, 870nm, 44.4 mW/cm2, 26 J/cm2 Intranasal: 810nm, 7.6 mW/cm2, 44 J/cm2 Intervention2: Light therapy- Near Infrared: Transcranial: 633nm,

Eligibility

Inclusion criteria

Inclusion criteria: 1. Able to provide informed consent 2. Willingness to be randomized to Sham or Real stimulation groups 3. Willingness to undergo two brain MRI-MRS scans and commit time necessary for the study 4. Lives independently with no impairment in social or occupational function • At least 8th grade education • Scores > 25 on Hindi Mental State Examination • On stable doses of major medications for last 3 months • Score < 14 on the Beck Depression Inventory-II

Exclusion criteria

Exclusion criteria: 1. Unstable and uncontrolled medical conditions; diagnosis of cancer 2. Previous major strokes or other known significant brain abnormalities, diseases, or disorders affecting cognition 3. Evidence of mild cognitive impairment or potential dementia, meeting DSM-V criteria for Major or Minor Neurocognitive Disorder 4. Current or past history of major psychiatric disturbance • Use of antipsychotics, sedatives, or other medications with significant anticholinergic properties (due to potential influence on memory) • Use of photo-sensitive medications within 15 days of the study intervention • Presence of claustrophobia • Implants such as pacemakers, heart vales, brain aneurysm clips, orthodontics, non-removable body jewelry, or shrapnel containing ferromagnetic metal

Design outcomes

Primary

Measure	Time frame
Functional Brain activity through resting state fMRITimepoint: Pre Immediate	—

Secondary

Measure	Time frame
Creatinine/NAA ratio in prefrontal cortexTimepoint: Pre Immediate;Executive function-Working MemoryTimepoint: Pre Immediate;Global cognitive functionTimepoint: Pre Immediate;Glutamate/GABA ratio in Prefrontal cortexTimepoint: Pre Immediate;N-Acetyl Aspartate/ Myo-inositol ratio in prefrontal cortexTimepoint: Pre Immediate	—

Countries

India

Contacts

Public ContactPreeti Sinha

National Institute of Mental Health And Neurosciences (NIMHANS)

drpreetisinha@gmail.com9243328988

Outcome results