Health Condition 1: null- Schizophrenia
Conditions
Interventions
Intervention1: True High Definition trans-cranial Direct Current Stimulation (HD-tDCS): It is a non invasive neuromodulatory brain stimulation technique that delivers low intensity direct current, usi
Sponsors
National Institute of Mental health and Neurosciences
Eligibility
Inclusion criteria
Inclusion criteria: 1) Diagnosis of schizophrenia / schizophreniform disorder as per DSM criteria (Diagnostic and Statistical Manual for Mental Disorders, American Psychiatric Association); 2) Persistent auditory hallucination despite adequate antipsychotic medication (atleast one antipsychotic trial) with unchanged dose at least for the past 4 weeks. 3) Clinically Significant Auditory Verbal Hallucinations as defined by a structured rating scale for assessing auditory hallucination; 4) Age range: 18 â?? 45 years; 5) Both sexes; 6) Right Handedness and 7) Having satisfactory capacity to consent. 8) Written informed consent.
Exclusion criteria
Exclusion criteria: 1) Features suggestive of psychiatric emergency (for example: suicidal risk, aggression, excitement, catatonia, prolonged nutritional deprivation or any other status requiring intensive clinical care), 2) Any contraindication to HD-tDCS procedure â?? (i) metal in the head, (ii) implanted brain medical devices, (iii) local lesion or injury in the scalp / head, 3) Any concurrent co-morbid psychiatric diagnosis; 4) Pregnancy or post-partum status; 5) Any contraindication for MRI; and 6) Left Handedness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Severity of auditory hallucinations. 2. Change in the neural correlates involved in auditory hallucinations(Using brain imaging techniques like structural MRI, resting fMRI and DTI) Timepoint: Twice. First day (Day 0), before the treatment with HD-tDCS is given. And second on the last day(day 5), after the second session of HD-tDCS treatment is over. | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of positive and negative symptomsTimepoint: Twice. First day (Day 0), before the treatment with HD-tDCS is given. And second on the last day(day 5), after the second session of HD-tDCS treatment is over. | — |
Countries
India
Contacts
Public ContactDr Rujuta U Parlikar
National Institute of Mental Health and Neurosciences
Outcome results
None listed