Health Condition 1: null- Patients undergoing sergical procedures PAC fit
Conditions
Interventions
Control Intervention1: The comparison of two combinations 1)Propofol and Ketamine 2) Propofol and Dexmedetomedine.: Induction of anesthesia will be done in group 1) with Propofol 1.0 mg/Kgbwt and Keta
Sponsors
Peoples College of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 100 adult patients with ASA Gr I-II between age of 18 to 65 years of age willing for participation in study after explanation of study undergoing short surgical procedures will be includd.They will be devided in two groups 1) group will receive Propofol- Ketamine. combination and group 2) will receive Propofol Dexamedetomedine combination. One capsule of Omeprazole 20 mg and one tab of Alprozolam 0.25 mg given at 10.00 PM previous night of procedure.IV fluid Ringer Lactate will be given for fluid resuscitation. Inductio of anesthesia will be done ingroup 1) with Propofol 1.0 mg/Kgbwt and Ketamine 1.0 mg body wt in group 2) with Propofol 1.0 mg/ bodt wt and Dexmedetomedine 1.0 mg body wt. Maintenance with Propofol 2.0 mg and Ketamine 2.0 mg per kg per hour in group 1) and with Propofol 2.0 mg and Dexmedetomedine 0.7 mg per kg per hour in gropup 2). The vital parameters will be observed during operative procedure and postoperative period. The patients will be followed up for any symptoms and signs and vitals recorded in recovery room.
Exclusion criteria
Exclusion criteria: Patients who didnot give consent for participation. Patients with H/O allergy to any particular drug, allergy to egg or fat, on MAO inhibitors, H/O Liver disorder like jaundice etc. Pregnant woman and patients for long surgeries not included in study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parameters SpO2, NIBP, ECG and heart rate monitored at interval of 5 min for initial 15 min and then every 10 min interval till end. Patients in both groups were ventilated with 100% Oxygen through circuit attached to circle absorber. All patients in both groups were monitored and followed up in post operative period for any symptoms. The vitals were recorded at 15 min interval in recovery room. It was presumed to have some changes in parameters. Timepoint: Side effects if any with the combinations. Change in vital parameters during procedures and in immediate post operative period were noted | — |
Secondary
| Measure | Time frame |
|---|---|
| There was slight increase in pulse rate in both groups,insignificant change in Blood Pressure,time of drowsiness was more in Ketamine group,nausea and vomiting were comparable in bothTimepoint: There was slight increase in pulse rate in both groups which persisted for brief period of 35 min.,insignificant change in Blood Pressure,time of drowsiness was more in Ketamine group in recovery period, nausea and vomiting were comparable in both | — |
Countries
India
Contacts
Public ContactDr Kanhaiya Lal Kishnani
Peoples College of Medical Sciences & Research Centre
Outcome results
None listed