comparing oral melatonin with oral clonidine as a drug given before anaesthesia, on anaesthetic usage and post operative pain in patients undergoing general anaesthesia

Comparison of oral melatonin and clonidine as premedication on isoflurane consumption and postoperative analgesia in patients undergoing general anaesthesiaâ?? A randomised controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/02/012032

Enrollment

Registered

2018-02-21

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA 1 patients undergoing general anaesthesia

Interventions

Intervention1: melatonin and clonidine: tab melatonin 3mg and tab clonidine 100microgram Control Intervention1: melatonin, clonidine, control: tab melatonin 3mg, clonidine 100microgram and placebo con

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients who give written informed consent (Annexure I) 2) Patients belonging to ASA Grade I and II (Annexure II) 3) Age between 18-60 yrs 4) BMI between 18.9- 24.9 kg/m2

Exclusion criteria

Exclusion criteria: 1) Patient refusal 2) Patients with systemic disorders 3) Patients with psychiatric illness

Design outcomes

Primary

Measure	Time frame
To compare the effects of oral melatonin and clonidine as premedication on 1) isoflurane consumption 2) postoperative analgesia Timepoint: Isoflurane consumption: every 30minutes till the end of surgery Post operative analgesia: till the visual analogue scale is more than 5	—

Secondary

Measure	Time frame
to study the safety profile of melatonin and clonidineTimepoint: 1	—

Countries

India

Contacts

Public ContactDr Ranjitha Gangadharaiah

bangalore medical college and research institute

ranjithagangadharaiah@gmail.com9880243626

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026