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Role of Beta Blocker (Drug) in Patients With Acute-on-chronic Liver Failure (liver Disease).

Efficacy of Nonselective Beta Blocker vs Placebo in Patients With Acute-on-chronic Liver Failure With Small/ no Esophageal Varices

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/02/012024
Enrollment
250
Registered
2018-02-21
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Acute on Chronic Liver Failure Health Condition 2: K721- Chronic hepatic failure

Interventions

Intervention1: Carvedilol: Carvedilol 3.125 mg followed by 6.25 mg twice daily Route of administration-oral route Total duration-3 months Control Intervention1: Placebo: Placebo will be given in the s

Sponsors

Institute of liver and Biliary Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1)Acute on Chronic Liver Failure as per APASL (Asian Pacific Association of Study of Liver Disease) criteria. 2)18-75 years 3)HVPG more than 12 with No/Small Esophageal varices

Exclusion criteria

Exclusion criteria: 1) Bradycardia (HR 2) Hypotension 3) Asthma 4) LVF 5) AKI (Acute Kidney Injury) 6) Refractory ascites 7) SBP (Spontaneous Bacterial Peritonitis)

Design outcomes

Primary

MeasureTime frame
Development of Esophageal Variceal bleedingTimepoint: during 3 months—

Secondary

MeasureTime frame
Adverse EventsTimepoint: 3 months;Improvement in liver severity scoresTimepoint: 3 month;Progression of esophageal varicesTimepoint: During 3 months;Reduction in portal pressure/LSM (Liver Stiffness Measurement)/esophageal VaricesTimepoint: 3 months;SurvivalTimepoint: 3 months;Transplant free survival/spontaneous recoveryTimepoint: 3 months—

Countries

India

Contacts

Public ContactDr Sumeet Kainth

Institute of Liver and Biliary Sciences

shivsarin@gmail.com01146300000

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026