Health Condition 1: null- ASA I &II patients posted for elective surgeries under general anesthesia
Conditions
Interventions
Intervention1: inj dexmedetomidien 1mcg/kg infusion and inj propofol: On arrival in the operating room, the patients baseline heart rate, blood pressure and oxygen saturation (SpO 2) will be recorded
Sponsors
none
Eligibility
Inclusion criteria
Inclusion criteria: 1.ASA I or II (no or minimal co-morbid disease) 2.Patients scheduled for elective surgeries
Exclusion criteria
Exclusion criteria: 1.History of allergy or contraindications study drug 2.Concomitant use of medications which may exaggerate the heart rate response of Dexmedetomidine including digoxin or ß-adrenergic antagonists. 3.Predicted difficulty in intubation, 4.pregnant patients 5.nursing women 6.morbid obesity 7.Coronary artery disease 8.ischemic heart disease 9.heart blocks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary objective: 1.To compare the Mean Arterial Pressure and Heart Rate response to induction with Propofol and Sevoflurane after dexmedetomidine 1 ? g/kg IV infusion. 2.To compare effectiveness of Dexmedetomidine 1 ? g/kg with propofol and Dexmedetomidine 1 ? g/kg with sevoflurane in attenuating cardiovascular response during laryngoscopy and intubationTimepoint: 1. 5min after settling in OT 2. 2 min after administration of drug, 3.1min after induction and 4.at 1, 3, 5 and 10 min after intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objective: To compare time of induction and smoothness of inductionTimepoint: The time of start of injection of propofol or mask placement with sevoflurane 8% was considered as ‘starting point of induction’. The patients were asked every 5 seconds, to open the eyes and loss of response to this command was defined as loss of verbal contact. Eyelash reflex will be then checked for additional confirmation of loss of consciousness which is defined as ‘induction end point’. The time taken for anesthetic induction will be recorded for both groups | — |
Countries
India
Contacts
Public ContactDr Navya C N
Sri MuthuKumaran Medical College, Hospital And Research Institute,
Outcome results
None listed